References

References

  1. https://www.who.int/medicines/access/controlled-substances/CannabidiolCriticalReview.pdf
  2. https://www.fda.gov/consumers/consumer-updates/what-you-need-know-and-what-were-working-find-out-about-products-containing-cannabis-or-cannabis
  3. Williams D, Stone M, Hauck P, Rahman S. 1989. Why are Secondary Metabolites (Natural Products) Biosynthesized. Journal of Natural Products, 59(6), pp. 1189-1208. 
  4. Goodman, N. 2011. An Overview of the Cannabinoid System. The Vaults of Erowid, v 1.3, https://www.erowid.org/plants/cannabis/cannabis_pharmacology2.shtml.
  5. Nadal  X, del Rio C, Casano S, Palomares  B, Ferreiro-Vera C, Navarrette C, Sánchez-Carnerero C, Cantarero I, Bellido, ML, Meyer S, Morello G, Appendino G, Muñoz E. 2017. Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity. British Journal of Pharmacology, 174, pp. 4263-4276.
  6. Rock EM, Limebeer CL, Parker LA. 2018. Effect of cannabidiolic acid and ∆<sup>9</sup>-tetrahydrocannabinol on carrageenan-induced hyperalgesia and edema in a rodent model of inflammatory pain. Psychopharmacology (Berl).;235(11):3259-3271. 
  7. Izzo, A. A. et al., 2009. Non-psychotropic plant cannabinoids new therapeutic opportunities from an ancient herb. Cell Press, pp. 515-527.
  8. Bolognini, D., Rock, E. M., Cluny, N. L., Cascio, M. G., Limebeer, C. L., Duncan, M., Stott, C. G., Javid, F. A., Parker, L. A., … Pertwee, R. G. (2013). Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation. British journal of pharmacology168(6), 1456-70.
  9. Takeda, S. et. al., 2008.   Cannabidiolic Acid as a Selective Cyclooxygenase-2 Inhibitory Component in Cannabis.  Drug Metabolism and Disposition, 36 (9), pp. 1917-21.
  10. Takeda, S. et al., 2014. Cannabidiolic acid had dual inhibitory effects on COX-2 through down-regulation and enzyme inhibition, and may suppress genes that are positively involved in the metastasis of cancer cells in vitro.. J. Toxicol Sci., 39(5), pp. 711-716.
  11. Takeda, S. et al., 2016. Cannabidiolic acid abrogates the expression of COX-2 via the selective down-regulation of c-fos. J Nat Med..
  12. a) Takeda, S. et al., 2012. Cannabidiolic acid an active component in the cannabis plant offers potential therapeutic modality in the aborgation of cancer cell migration. Toxicol Let., 214(3), pp. 314-9. b) Takeda, S., Okajima, S., Miyoshi, H., Yoshida, K., Okamoto, Y., Okada, T., Amamoto, T., Watanabe, K., Omiecinski, C. J., … Aramaki, H. (2012). Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration. Toxicology letters214(3), 314-9.
  13. https://chylocure.com/wp-content/uploads/2020/09/Towards-Better-Delivery-of-Cannabidiol-CBD.pdf
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